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Impact of human D398N single nucleotide polymorphism on intracellular calcium response mediated by α3β4α5 nicotinic acetylcholine receptors

The human CHRNA5 D398N polymorphism (rs16969968) causes an aspartic acid to asparagine change in the nicotinic acetylcholine receptor (nAChR) α5 subunit gene. The N398 variant of CHRNA5 is linked to increased risk for nicotine dependence. In this study, we explored the effect of the CHRNA5 D398N pol...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Tammimäki, Anne, Herder, Penelope, Li, Ping, Esch, Caroline, Laughlin, James R., Akk, Gustav, Stitzel, Jerry A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2012
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661904/
https://ncbi.nlm.nih.gov/pubmed/22820273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2012.07.022
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