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Enhanced NF-κB Activity Impairs Vascular Function Through PARP-1–, SP-1–, and COX-2–Dependent Mechanisms in Type 2 Diabetes
Type 2 diabetes (T2D) is associated with vascular dysfunction. We hypothesized that increased nuclear factor-κB (NF-κB) signaling contributes to vascular dysfunction in T2D. We treated type 2 diabetic (db(−)/db(−)) and control (db(−)/db(+)) mice with two NF-κB inhibitors (6 mg/kg dehydroxymethylepox...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Diabetes Association
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3661639/ https://ncbi.nlm.nih.gov/pubmed/23349490 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1374 |
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