Chromatin structure of two genomic sites for targeted transgene integration in induced pluripotent stem cells and hematopoietic stem cells

Achieving transgene integration into preselected genomic sites is currently one of the central tasks in stem cell gene therapy. A strategy to mediate such targeted integration involves site specific endonucleases. Two genomic sites within the MBS85 and CCR5 genes [AAVS1 and CCR5 zinc finger nuclease...

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Detalhes bibliográficos
Main Authors: van Rensburg, Ruan, Beyer, Ines, Yao, Xiao-Ying, Wang, Hongjie, Denisenko, Oleg, Li, Zong-Yi, Russell, David W., Miller, Daniel G., Gregory, Philip, Holmes, Michael, Bomsztyk, Karol, Lieber, André
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661409/
https://ncbi.nlm.nih.gov/pubmed/22436965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2012.25
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