Cisplatin-induced caspase activation mediates PTEN cleavage in ovarian cancer cells: a potential mechanism of chemoresistance

BACKGROUND: The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) tumor suppressor protein is a central negative regulator of the PI3K/AKT signaling cascade and suppresses cell survival as well as cell proliferation. PTEN is found to be either inactivated or mutated in various human mal...

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Detaylı Bibliyografya
Asıl Yazarlar: Singh, Mohan, Chaudhry, Parvesh, Fabi, Francois, Asselin, Eric
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661380/
https://ncbi.nlm.nih.gov/pubmed/23663432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-233
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