Phase I trial of capecitabine rapidly disintegrating tablets and concomitant radiation therapy in children with newly diagnosed brainstem gliomas and high-grade gliomas

BACKGROUND: We conducted a phase I study to estimate the maximum tolerated dose and describe the dose-limiting toxicities and pharmacokinetics of oral capecitabine rapidly disintegrating tablets given concurrently with radiation therapy to children with newly diagnosed brainstem or high-grade glioma...

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Detalhes bibliográficos
Main Authors: Kilburn, Lindsay B., Kocak, Mehmet, Schaedeli Stark, Franziska, Meneses-Lorente, Georgina, Brownstein, Carrie, Hussain, Sazzad, Chintagumpala, Murali, Thompson, Patrick A., Gururangan, Sri, Banerjee, Anuradha, Paulino, Arnold C., Kun, Larry, Boyett, James M., Blaney, Susan M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Clinical Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661085/
https://ncbi.nlm.nih.gov/pubmed/23592571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos315
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