Combined Genetic Inactivation of Beta2-Microglobulin and CD58 Reveals Frequent Escape from Immune Recognition in Diffuse Large B-cell Lymphoma

We report that diffuse large B-cell lymphoma (DLBCL) commonly fails to express cell-surface molecules necessary for the recognition of tumor cells by immune-effector cells. In 29% of cases, mutations and deletions inactivate the β2-microglobulin gene, thus preventing the cell-surface expression of t...

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Autori principali: Challa-Malladi, Madhavi, Lieu, Yen K., Califano, Olivia, Holmes, Antony, Bhagat, Govind, Murty, Vundavalli V., Dominguez-Sola, David, Pasqualucci, Laura, Dalla-Favera, Riccardo
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660995/
https://ncbi.nlm.nih.gov/pubmed/22137796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.11.006
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