High-Throughput Screening for GPR119 Modulators Identifies a Novel Compound with Anti-Diabetic Efficacy in db/db Mice

G protein-coupled receptor 119 (GPR119) is highly expressed in pancreatic β cells and enteroendocrine cells. It is involved in glucose-stimulated insulin secretion and glucagon-like peptide-1 (GLP-1) release, thereby representing a promising target for the treatment of type 2 diabetes. Although a nu...

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Main Authors: Zhang, Meng, Feng, Yang, Wang, Jia, Zhao, Jianwei, Li, Ting, He, Min, Yang, Dehua, Nosjean, Olivier, Boutin, Jean, Renard, Pierre, Wang, Ming-Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660563/
https://ncbi.nlm.nih.gov/pubmed/23704946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063861
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