Tumor Necrosis Factor-α and Lymphotoxin-α Mediate Myocardial Ischemic Injury via TNF Receptor 1, but Are Cardioprotective When Activating TNF Receptor 2

OBJECTIVE: This study determines the roles of tumor necrosis factor-α (TNFα) and lymphotoxin-α (LTα) in post-myocardial infarction (post-MI) cardiac injury, and identifies the TNF receptor type responsible for TNFα- and LTα-mediated cardiac injury. METHODS AND RESULTS: Adult male wild type (WT), TNF...

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Detalhes bibliográficos
Main Authors: Zhang, Yanqing, Zhao, Jianli, Lau, Wayne Bond, Jiao, Li-Yuan, Liu, Baojiang, Yuan, Yuexing, Wang, Xiaoliang, Gao, Erhe, Koch, Walter J., Ma, Xin-Liang, Wang, Yajing
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660398/
https://ncbi.nlm.nih.gov/pubmed/23704873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060227
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