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Compartmentalization of metabolic pathways in yeast mitochondria improves production of branched chain alcohols

Efforts to improve the production of a compound of interest in Saccharomyces cerevisiae have mainly involved engineering or overexpression of cytoplasmic enzymes. We show that targeted expression of metabolic pathways to mitochondria can increase production levels compared with expression of the sam...

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Detalhes bibliográficos
Main Authors: Avalos, José L., Fink, Gerald R., Stephanopoulos, Gregory
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659820/
https://ncbi.nlm.nih.gov/pubmed/23417095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2509
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