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New insights in the mechanism of microRNA-mediated target repression
The microRNA-induced silencing complex (miRISC) protein TNRC6 (also called GW182) uses dispersed tryptophan-containing repeats in unstructured regions to recruit the CCR4–NOT nuclease complex leading to mRNA deadenylation and inhibition of translation initiation according to new research.
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3659398/ https://ncbi.nlm.nih.gov/pubmed/22056803 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2170 |
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