The negative impact of α-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation

A decline in α-ketoglutarate dehydrogenase complex (KGDHC) activity has been associated with neurodegeneration. Provision of succinyl-CoA by KGDHC is essential for generation of matrix ATP (or GTP) by substrate-level phosphorylation catalyzed by succinyl-CoA ligase. Here, we demonstrate ATP consumpt...

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Detalhes bibliográficos
Main Authors: Kiss, Gergely, Konrad, Csaba, Doczi, Judit, Starkov, Anatoly A., Kawamata, Hibiki, Manfredi, Giovanni, Zhang, Steven F., Gibson, Gary E., Beal, M. Flint, Adam-Vizi, Vera, Chinopoulos, Christos
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2013
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659355/
https://ncbi.nlm.nih.gov/pubmed/23475850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-220202
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