RNA interference-mediated FANCF silencing sensitizes OVCAR3 ovarian cancer cells to adriamycin through increased adriamycin-induced apoptosis dependent on JNK activation

In the present study, we downregulated FANCF expression by small interfering RNA (siRNA) in OVCAR ovarian cancer cells to address the effects of decreased FANCF expression on the function of the Fanconi anemia (FA)/breast cancer susceptibility gene (BRCA) pathway. Furthermore, we investigated whethe...

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Main Authors: HE, MIAO, SUN, HAI-GANG, HAO, JUN-YING, LI, YAN-LIN, YU, JIAN-KUN, YAN, YUAN-YUAN, ZHAO, LIN, LI, NA, WANG, YAN, BAI, XUE-FENG, YU, ZHAO-JIN, ZHENG, ZHI-HONG, MI, XIAO-YI, WANG, EN-HUA, WEI, MIN-JIE
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3658863/
https://ncbi.nlm.nih.gov/pubmed/23440494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2013.2295
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