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Glycosylation Site-Specific Analysis of HIV Envelope Proteins (JR-FL and CON-S) Reveals Major Differences in Glycosylation Site Occupancy, Glycoform Profiles, and Antigenic Epitopes’ Accessibility

The HIV-1 envelope (Env) is a key determinant in mediating viral entry and fusion to host cells and is a major target for HIV vaccine development. While Env is typically about 50% glycan by mass, glycosylation sites are known to evolve, with some glycosylation profiles presumably being more effectiv...

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Dettagli Bibliografici
Autori principali: Go, Eden P., Irungu, Janet, Zhang, Ying, Dalpathado, Dilusha S., Liao, Hua-Xin, Sutherland, Laura L., Alam, S. Munir, Haynes, Barton F., Desaire, Heather
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3658474/
https://ncbi.nlm.nih.gov/pubmed/18330979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr7006957
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