Short hairpin RNA interference therapy for ischemic heart disease

BACKGROUND: During hypoxia, upregulation of hypoxia inducible factor-1 alpha (HIF-1α) transcriptional factor can activate several downstream angiogenic genes. However, HIF-1α is naturally degraded by prolyl hydroxylase-2 (PHD2) protein. Here we hypothesize that short hairpin RNA (shRNA) interference...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Huang, Mei, Chan, Denise, Jia, Fangjun, Xie, Xiaoyan, Li, Zongjin, Hoyt, Grant, Robbins, Robert C., Chen, Xiaoyuan, Giaccia, Amato, Wu, Joseph C.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2008
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3657507/
https://ncbi.nlm.nih.gov/pubmed/18824759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.107.760785
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