Nucleoside Reverse Transcriptase Inhibitor Resistance Mutations Associated with First-Line Stavudine-Containing Antiretroviral Therapy: Programmatic Implications for Countries Phasing Out Stavudine

BACKGROUND: The World Health Organization Antiretroviral Treatment Guidelines recommend phasing-out stavudine because of its risk of long-term toxicity. There are two mutational pathways of stavudine resistance with different implications for zidovudine and tenofovir cross-resistance, the primary ca...

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Main Authors: Tang, Michele W., Rhee, Soo-Yon, Bertagnolio, Silvia, Ford, Nathan, Holmes, Susan, Sigaloff, Kim C., Hamers, Raph L., de Wit, Tobias F. Rinke, Fleury, Herve J., Kanki, Phyllis J., Ruxrungtham, Kiat, Hawkins, Claudia A., Wallis, Carole L., Stevens, Wendy, van Zyl, Gert U., Manosuthi, Weerawat, Hosseinipour, Mina C., Ngo-Giang-Huong, Nicole, Belec, Laurent, Peeters, Martine, Aghokeng, Avelin, Bunupuradah, Torsak, Burda, Sherri, Cane, Patricia, Cappelli, Giulia, Charpentier, Charlotte, Dagnra, Anoumou Y., Deshpande, Alaka K., El-Katib, Ziad, Eshleman, Susan H., Fokam, Joseph, Gody, Jean-Chrysostome, Katzenstein, David, Koyalta, Donato D., Kumwenda, Johnstone J., Lallemant, Marc, Lynen, Lutgarde, Marconi, Vincent C., Margot, Nicolas A., Moussa, Sandrine, Ndung'u, Thumbi, Nyambi, Phillipe N., Orrell, Catherine, Schapiro, Jonathan M., Schuurman, Rob, Sirivichayakul, Sunee, Smith, Davey, Zolfo, Maria, Jordan, Michael R., Shafer, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
The Impact of HIV Drug Resistance on the Selection of 1st- and 2nd-Line Art in Resource-Limited Settings
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3657117/
https://ncbi.nlm.nih.gov/pubmed/23687292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jit114
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