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Imprint of evolution on protein structures
We attempt to understand the evolutionary origin of protein folds by simulating their divergent evolution with a three-dimensional lattice model. Starting from an initial seed lattice structure, evolution of model proteins progresses by sequence duplication and subsequent point mutations. A new gene...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2004
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC365708/ https://ncbi.nlm.nih.gov/pubmed/14970345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0306638101 |
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