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Imprint of evolution on protein structures

We attempt to understand the evolutionary origin of protein folds by simulating their divergent evolution with a three-dimensional lattice model. Starting from an initial seed lattice structure, evolution of model proteins progresses by sequence duplication and subsequent point mutations. A new gene...

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Autors principals: Tiana, Guido, Shakhnovich, Boris E., Dokholyan, Nikolay V., Shakhnovich, Eugene I.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC365708/
https://ncbi.nlm.nih.gov/pubmed/14970345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0306638101
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