Transition state stabilization by general acid catalysis, water expulsion, and enzyme reorganization in Medicago savita chalcone isomerase

In aqueous solution, Medicago savita chalcone isomerase (CHI) enhances the reaction rate for the unimolecular rearrangement of chalcone (CHN) into flavanone by seven orders of magnitude. Conformations of CHN and their relative free energies in water and CHI were investigated by the thermodynamic per...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Hur, Sun, Newby, Zachary E. R., Bruice, Thomas C.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2004
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC365689/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14978275/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0308264100
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