Highly efficient reprogramming to pluripotency and directed differentiation of human cells using synthetic modified mRNA

Clinical application of induced pluripotent stem (iPS) cells is limited by the low efficiency of iPS derivation and the fact that most protocols modify the genome to effect cellular reprogramming. Moreover, safe and effective means of directing the fate of patient-specific iPS cells towards clinical...

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Bibliografiska uppgifter
Huvudupphovsmän: Warren, Luigi, Manos, Philip D., Ahfeldt, Tim, Loh, Yuin-Han, Li, Hu, Lau, Frank, Ebina, Wataru, Mandal, Pankaj, Smith, Zachary D., Meissner, Alexander, Daley, George Q., Brack, Andrew S., Collins, James J., Cowan, Chad, Schlaeger, Thorsten M., Rossi, Derrick J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656821/
https://ncbi.nlm.nih.gov/pubmed/20888316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2010.08.012
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