Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway

Cancer cells exhibit metabolic dependencies that distinguish them from their normal counterparts(1). Among these addictions is an increased utilization of the amino acid glutamine (Gln) to fuel anabolic processes(2). Indeed, the spectrum of Gln-dependent tumors and the mechanisms whereby Gln support...

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Huvudupphovsmän: Son, Jaekyoung, Lyssiotis, Costas A., Ying, Haoqiang, Wang, Xiaoxu, Hua, Sujun, Ligorio, Matteo, Perera, Rushika M., Ferrone, Cristina R., Mullarky, Edouard, Shyh-Chang, Ng, Kang, Ya’an, Fleming, Jason B., Bardeesy, Nabeel, Asara, John M., Haigis, Marcia C., DePinho, Ronald A., Cantley, Lewis C., Kimmelman, Alec C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656466/
https://ncbi.nlm.nih.gov/pubmed/23535601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12040
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