Uric acid-induced endothelial dysfunction is associated with mitochondrial alterations and decreased intracellular ATP concentrations

BACKGROUND/AIMS: Endothelial dysfunction is associated with mitochondrial alterations. We hypothesized that uric acid, which can induce endothelial dysfunction in vitro and in vivo, might also alter mitochondrial function. METHODS: Human aortic endothelial cells were exposed to soluble uric acid and...

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Main Authors: Sánchez-Lozada, Laura Gabriela, Lanaspa, Miguel A., Cristóbal-García, Magdalena, García-Arroyo, Fernando, Soto, Virgilia, Cruz-Robles, David, Nakagawa, Takahiko, Yu, Min-A, Kang, Duk-Hee, Johnson, Richard J
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656428/
https://ncbi.nlm.nih.gov/pubmed/23235493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000345509
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