High Mobility Group Box-1 Promotes the Proliferation and Migration of Hepatic Stellate Cells via TLR4-Dependent Signal Pathways of PI3K/Akt and JNK

BACKGROUND: The migration of hepatic stellate cells (HSCs) is essential to the hepatic fibrotic response, and recently High-mobility group box 1 (HMGB1) has been shown up-regulated during liver fibrosis. Nevertheless, whether HMGB1 can modulate the proliferation and migration of HSCs is poorly under...

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Bibliographische Detailangaben
Hauptverfasser: Wang, Fu-ping, Li, Lei, Li, Jing, Wang, Ji-yao, Wang, Ling-yan, Jiang, Wei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3655989/
https://ncbi.nlm.nih.gov/pubmed/23696886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064373
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