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Delayed and Persistent ERK1/2 Activation Is Required for 4-Hydroxytamoxifen-induced Cell Death
Tamoxifen (Tam), and its active metabolite, 4-hydroxytamoxifen (OHT), compete with estrogens for binding to the estrogen receptor (ER). Tam and OHT can also induce ER-dependent apoptosis of cancer cells. 10–100 nM OHT induces ER-dependent apoptosis in ~3 days. Using HeLaER6 cells, we examined the ro...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3655899/ https://ncbi.nlm.nih.gov/pubmed/17714751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.steroids.2007.06.007 |
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