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Molecular diversity and population structure at the Cytochrome P450 3A5 gene in Africa

BACKGROUND: Cytochrome P450 3A5 (CYP3A5) is an enzyme involved in the metabolism of many therapeutic drugs. CYP3A5 expression levels vary between individuals and populations, and this contributes to adverse clinical outcomes. Variable expression is largely attributed to four alleles, CYP3A5*1 (expre...

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Detalhes bibliográficos
Main Authors: Bains, Ripudaman K, Kovacevic, Mirna, Plaster, Christopher A, Tarekegn, Ayele, Bekele, Endashaw, Bradman, Neil N, Thomas, Mark G
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3655848/
https://ncbi.nlm.nih.gov/pubmed/23641907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2156-14-34
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