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The nascent polypeptide-associated complex is a key regulator of proteostasis

The adaptation of protein synthesis to environmental and physiological challenges is essential for cell viability. Here, we show that translation is tightly linked to the protein-folding environment of the cell through the functional properties of the ribosome bound chaperone NAC (nascent polypeptid...

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Detalhes bibliográficos
Main Authors: Kirstein-Miles, Janine, Scior, Annika, Deuerling, Elke, Morimoto, Richard I
Formato: Artigo
Idioma:Inglês
Publicado em: European Molecular Biology Organization 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3655472/
https://ncbi.nlm.nih.gov/pubmed/23604074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.87
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