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Metal-free α-Amination of Secondary Amines: Computational and Experimental Evidence for Azaquinone Methide and Azomethine Ylide Intermediates

We have performed a combined computational and experimental study to elucidate the mechanism of a metal-free α-amination of secondary amines. Calculations predicted azaquinone methides and azomethine ylides as the reactive intermediates and showed that iminium ions are unlikely to participate in the...

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Bibliografiske detaljer
Main Authors: Dieckmann, Arne, Richers, Matthew T., Platonova, Alena Yu., Zhang, Chen, Seidel, Daniel, Houk, K. N.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654248/
https://ncbi.nlm.nih.gov/pubmed/23517448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo400483h
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