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Allosteric modulation and functional selectivity of G protein-coupled receptors
Agonists of a single G protein-coupled receptor (GPCR) may activate distinct signaling pathways. Functional selectivity, an emerging concept with therapeutic relevance for GPCRs, may be due to conformational selection or stabilization with respect to particular agonists, receptor dimerization, varia...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3653340/ https://ncbi.nlm.nih.gov/pubmed/24050274 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ddtec.2012.08.004 |
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