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Allosteric modulation and functional selectivity of G protein-coupled receptors

Agonists of a single G protein-coupled receptor (GPCR) may activate distinct signaling pathways. Functional selectivity, an emerging concept with therapeutic relevance for GPCRs, may be due to conformational selection or stabilization with respect to particular agonists, receptor dimerization, varia...

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Detalles Bibliográficos
Main Authors: Gao, Zhan-Guo, Jacobson, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3653340/
https://ncbi.nlm.nih.gov/pubmed/24050274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ddtec.2012.08.004
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