Albumin and alpha-fetoprotein gene transcription in rat hepatoma cell lines is correlated with specific DNA hypomethylation and altered chromatin structure in the 5' region.

We examined DNA methylation and DNase I hypersensitivity of the alpha-fetoprotein (AFP) and albumin gene region in hepatoma cell lines which showed drastic differences in the level of expression of these genes. We assayed for methylation of the CCGG sequences by using the restriction enzyme isoschiz...

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Detalles Bibliográficos

Publicado en:	Mol Cell Biol
Principais autores:	Tratner, I, Nahon, J L, Sala-Trepat, J M, Venetianer, A
Formato:	Artigo
Idioma:	Inglês
Publicado:	Taylor & Francis 1987
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC365289/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2439898/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.7.5.1856-1864.1987
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