A Human Anti-c-Met Fab Fragment Conjugated with Doxorubicin as Targeted Chemotherapy for Hepatocellular Carcinoma

c-Met is over-expressed in hepatocellular carcinoma(HCC) but is absent or expressed at low levels in normal tissues. Therefore we generated a novel conjugate of a human anti-c-Met Fab fragment (MetFab) with doxorubicin (DOX) and assessed whether it had targeted antitumor activity against HCC and red...

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Detalhes bibliográficos
Main Authors: Chen, Ximin, Ding, Guipeng, Gao, Qihe, Sun, Jian, Zhang, Qianqian, Du, Lijian, Qiu, Zhenning, Wang, Changjun, Zheng, Feng, Sun, Bowang, Ni, Jian, Feng, Zhenqing, Zhu, Jin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3652865/
https://ncbi.nlm.nih.gov/pubmed/23675455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063093
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