The sterol regulatory element binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

Newly activated CD8(+) T cells reprogram their metabolism to meet the extraordinary biosynthetic demands of clonal expansion; however, the signals mediating metabolic reprogramming remain poorly defined. Herein, we demonstrate an essential role for sterol regulatory element binding proteins (SREBPs)...

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Detalhes bibliográficos
Main Authors: Kidani, Yoko, Elsaesser, Heidi, Hock, M Benjamin, Vergnes, Laurent, Williams, Kevin J, Argus, Joseph P, Marbois, Beth N, Komisopoulou, Evangelia, Wilson, Elizabeth B, Osborne, Timothy F, Graeber, Thomas G, Reue, Karen, Brooks, David G, Bensinger, Steven J
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3652626/
https://ncbi.nlm.nih.gov/pubmed/23563690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2570
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