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High doses of dextromethorphan, an NMDA antagonist, produce effects similar to classic hallucinogens

RATIONALE: Although reports of dextromethorphan (DXM) abuse have increased recently, few studies have examined the effects of high doses of DXM. OBJECTIVE: This study in humans evaluated the effects of supratherapeutic doses of DXM and triazolam. METHODS: Single, acute, oral doses of DXM (100, 200,...

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Detalhes bibliográficos
Main Authors: Reissig, Chad J., Carter, Lawrence P., Johnson, Matthew W., Mintzer, Miriam Z., Klinedinst, Margaret A., Griffiths, Roland R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3652430/
https://ncbi.nlm.nih.gov/pubmed/22526529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-012-2680-6
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