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Mechanisms by which transcription factors gain access to target sequence elements in chromatin
Transcription factors (TF) bind DNA sequence motifs, but the presence of a consensus DNA element is not sufficient to direct TF binding to chromatin. Recent genomic data have revealed that accessibility, as measured by DNase sensitivity and the presence of active histone marks, is necessary for TF b...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3651763/ https://ncbi.nlm.nih.gov/pubmed/23266217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gde.2012.11.008 |
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