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Recognition of mutant and cryptic 5' splice sites by the U1 small nuclear ribonucleoprotein in vitro.

We examined the ability of U1 small nuclear ribonucleoproteins (U1 snRNPs) to recognize mutant and cryptic 5' splice sites on beta-globin pre-mRNA substrates using an RNase T1 protection assay. When U1 snRNPs were prebound to anti-(U1)RNP antibodies, we detected binding to mutant but not to cryptic...

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Udgivet i:Mol Cell Biol
Principais autores: Chabot, B, Steitz, J A
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1987
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC365126/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2950313/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.7.2.698-707.1987
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