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p53 Mutagenesis by Benzo[a]pyrene derived Radical Cations
Benzo[a]pyrene (B[a]P), a major human carcinogen in combustion products such as cigarette smoke and diesel exhaust, is metabolically activated into DNA-reactive metabolites via three different enzymatic pathways. The pathways are the anti-(+)-benzo[a]pyrene 7,8-diol 9, 10-epoxide pathway (P450/ epox...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3650728/ https://ncbi.nlm.nih.gov/pubmed/22768918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx300201p |
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