The Tryptophan Residue at the Active Site Tunnel Entrance of Trichoderma reesei Cellobiohydrolase Cel7A Is Important for Initiation of Degradation of Crystalline Cellulose

The glycoside hydrolase family 7 cellobiohydrolase Cel7A from Trichoderma reesei is one of the best studied cellulases with the ability to degrade highly crystalline cellulose. The catalytic domain and the cellulose-binding domain (CBD) are both necessary for full activity on crystalline substrates....

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Main Authors: Nakamura, Akihiko, Tsukada, Takeshi, Auer, Sanna, Furuta, Tadaomi, Wada, Masahisa, Koivula, Anu, Igarashi, Kiyohiko, Samejima, Masahiro
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Enzymology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650387/
https://ncbi.nlm.nih.gov/pubmed/23532843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.452623
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