Integrated Proteomics Identified Novel Activation of Dynein IC2-GR-COX-1 Signaling in Neurofibromatosis Type I (NF1) Disease Model Cells

Neurofibromatosis type 1 (NF1) tumor suppressor gene product, neurofibromin, functions in part as a Ras-GAP, and though its loss is implicated in the neuronal abnormality of NF1 patients, its precise cellular function remains unclear. To study the molecular mechanism of NF1 pathogenesis, we prepared...

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Hauptverfasser: Hirayama, Mio, Kobayashi, Daiki, Mizuguchi, Souhei, Morikawa, Takashi, Nagayama, Megumi, Midorikawa, Uichi, Wilson, Masayo M., Nambu, Akiko N., Yoshizawa, Akiyasu C., Kawano, Shin, Araki, Norie
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2013
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650346/
https://ncbi.nlm.nih.gov/pubmed/23358504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M112.024802
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