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CD44 reciprocally regulates the differentiation of encephalitogenic Th1/Th17 and Th2/Treg cells through epigenetic modulation involving DNA methylation of cytokine gene promoters thereby controlling the development of experimental autoimmune encephalomyelitis
CD44 is expressed by variety of cells, including glial and T cells. Furthermore, in the demyelinating lesions of multiple sclerosis (MS), CD44 expression is chronically elevated. In this study, we demonstrate that targeted deletion of CD44 attenuated MOG peptide-induced experimental autoimmune encep...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3650091/ https://ncbi.nlm.nih.gov/pubmed/21551360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1004043 |
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