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Ammonia-induced brain swelling and neurotoxicity in an organotypic slice model

OBJECTIVES: Acute liver failure produces cerebral dysfunction and edema, mediated in part by elevated ammonia concentrations, often leading to coma and death. The pathophysiology of cerebral edema in acute liver failure is incompletely understood. In vitro models of the cerebral effects of acute liv...

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Main Authors: Back, Adam, Tupper, Kelsey Y., Bai, Tao, Chiranand, Paulpoj, Goldenberg, Fernando D., Frank, Jeffrey I., Brorson, James R.
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650023/
https://ncbi.nlm.nih.gov/pubmed/22196764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1179/1743132811Y.0000000046
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