Loss of Expression and Promoter Methylation of SLIT2 Are Associated with Sessile Serrated Adenoma Formation

Serrated adenomas form a distinct subtype of colorectal pre-malignant lesions that may progress to malignancy along a different molecular pathway than the conventional adenoma-carcinoma pathway. Previous studies have hypothesised that BRAF mutation and promoter hypermethylation plays a role, but the...

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Detalhes bibliográficos
Main Authors: Beggs, Andrew D., Jones, Angela, Shepherd, Neil, Arnaout, Abed, Finlayson, Caroline, Abulafi, A. Muti, Morton, Dion G., Matthews, Glenn M., Hodgson, Shirley V., Tomlinson, Ian P. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3649993/
https://ncbi.nlm.nih.gov/pubmed/23671423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003488
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