Gain-of-Sensitivity Mutations in a Trim5-Resistant Primary Isolate of Pathogenic SIV Identify Two Independent Conserved Determinants of Trim5α Specificity

Retroviral capsid recognition by Trim5 blocks productive infection. Rhesus macaques harbor three functionally distinct Trim5 alleles: Trim5α(Q), Trim5α(TFP) and Trim5(CypA). Despite the high degree of amino acid identity between Trim5α(Q) and Trim5α(TFP) alleles, the Q/TFP polymorphism results in th...

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Detalhes bibliográficos
Main Authors: McCarthy, Kevin R., Schmidt, Aaron G., Kirmaier, Andrea, Wyand, Allison L., Newman, Ruchi M., Johnson, Welkin E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3649984/
https://ncbi.nlm.nih.gov/pubmed/23675300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003352
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