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Allopregnanolone Elevations Following Pregnenolone Administration are Associated with Enhanced Activation of Emotion Regulation Neurocircuits

BACKGROUND: The neurosteroid allopregnanolone is a potent allosteric modulator of the GABA(A) receptor with anxiolytic properties. Exogenous administration of allopregnanolone reduces anxiety, and allopregnanolone blockade impairs social and affective functioning. However, the neural mechanism where...

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Detalhes bibliográficos
Main Authors: Sripada, Rebecca K., Marx, Christine E., King, Anthony P., Rampton, Jessica C., Ho, Shaun, Liberzon, Israel
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648625/
https://ncbi.nlm.nih.gov/pubmed/23348009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2012.12.008
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