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A Fully Attenuated Recombinant Salmonid Alphavirus Becomes Pathogenic through a Single Amino Acid Change in the E2 Glycoprotein
A recombinant sleeping disease virus (rSDV) was previously shown to be totally attenuated and provide long-term protection in trout (C. Moriette, M. Leberre, A. Lamoureux, T. L. Lai, M. Brémont, J. Virol. 80:4088–4098, 2006). Sequence comparison of the rSDV to wild-type genomes exhibited a number of...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3648200/ https://ncbi.nlm.nih.gov/pubmed/23449806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03501-12 |
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