Mucosal Priming with a Replicating-Vaccinia Virus-Based Vaccine Elicits Protective Immunity to Simian Immunodeficiency Virus Challenge in Rhesus Monkeys

Mucosal surfaces are not targeted by most human immunodeficiency virus type 1 (HIV-1) vaccines, despite being major routes for HIV-1 transmission. Here we report a novel vaccination regimen consisting of a mucosal prime with a modified replicating vaccinia virus Tiantan strain (MVTT(SIVgpe)) and an...

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Detalhes bibliográficos
Main Authors: Sun, Caijun, Chen, Zhiwei, Tang, Xian, Zhang, Yinfeng, Feng, Liqiang, Du, Yanhua, Xiao, Lijun, Liu, Li, Zhu, Weijun, Chen, Ling, Zhang, Linqi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648167/
https://ncbi.nlm.nih.gov/pubmed/23487457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03247-12
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