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The Source of the PB1 Gene in Influenza Vaccine Reassortants Selectively Alters the Hemagglutinin Content of the Resulting Seed Virus

The yields of egg-grown influenza vaccines are maximized by the production of a seed strain using a reassortment of the seasonal influenza virus isolate with a highly egg-adapted strain. The seed virus is selected based on high yields of viral hemagglutinin (HA) and expression of the surface antigen...

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Main Authors: Cobbin, Joanna C. A., Verity, Erin E., Gilbertson, Brad P., Rockman, Steven P., Brown, Lorena E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648160/
https://ncbi.nlm.nih.gov/pubmed/23468502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02856-12
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