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Age-Related Macular Degeneration-Associated Silent Polymorphisms in HtrA1 Impair Its Ability To Antagonize Insulin-Like Growth Factor 1

Synonymous single nucleotide polymorphisms (SNPs) within a transcript's coding region produce no change in the amino acid sequence of the protein product and are therefore intuitively assumed to have a neutral effect on protein function. We report that two common variants of high-temperature re...

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Detalhes bibliográficos
Main Authors: Jacobo, Sarah Melissa P., DeAngelis, Margaret M., Kim, Ivana K., Kazlauskas, Andrius
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3647976/
https://ncbi.nlm.nih.gov/pubmed/23478260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01283-12
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