Computational Design of Enone-Binding Proteins with Catalytic Activity for the Morita-Baylis-Hillman Reaction

The Morita-Baylis-Hillman reaction forms a carbon-carbon bond between the alpha carbon of a conjugated carbonyl compound and a carbon electrophile. The reaction mechanism involves Michael addition of a nucleophile catalyst at the carbonyl beta carbon, followed by bond formation with the electrophile...

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Detalhes bibliográficos
Main Authors: Bjelic, Sinisa, Nivon, Lucas G., Çelebi-Ölçüm, Nihan, Kiss, Gert, Rosewall, Carolyn F., Lovick, Helena M., Ingalls, Erica L., Gallaher, Jasmine Lynn, Seetharaman, Jayaraman, Lew, Scott, Montelione, Gaetano Thomas, Hunt, John Francis, Michael, Forrest Edwin, Houk, K. N., Baker, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3647451/
https://ncbi.nlm.nih.gov/pubmed/23330600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb3006227
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