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Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase.
Xenopus oocytes from unprimed frogs possess insulin-like growth factor I (IGF-I) receptors but lack insulin and IGF-I receptor substrate 1 (IRS-1), the endogenous substrate of this kinase, and fail to show downstream responses to hormonal stimulation. Microinjection of recombinant IRS-1 protein enha...
Kaydedildi:
Asıl Yazarlar: | , , , , , , |
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Materyal Türü: | Artigo |
Dil: | Inglês |
Baskı/Yayın Bilgisi: |
1993
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Konular: | |
Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC364728/ https://ncbi.nlm.nih.gov/pubmed/8413261 |
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