Combined modality doxorubicin-based chemotherapy and chitosan-mediated p53 gene therapy using double-walled microspheres for treatment of human hepatocellular carcinoma

The therapeutic efficiency of combined chemotherapy and gene therapy on human hepatocellular carcinoma HepG2 cells was investigated using double-walled microspheres that consisted of a poly(D,L-lactic-co-glycolic acid) (PLGA) core surrounded by a poly(L-lactic acid) (PLLA) shell layer and fabricated...

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Main Authors: Xu, Qingxing, Leong, Jiayu, Chua, Qi Yi, Chi, Yu Tse, Chow, Pierce Kah-Hoe, Pack, Daniel W., Wang, Chi-Hwa
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3646964/
https://ncbi.nlm.nih.gov/pubmed/23578555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2013.03.044
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