Inhibition of de novo ceramide biosynthesis by FTY720 protects rat retina from light-induced degeneration

Light-induced retinal degeneration (LIRD) in albino rats causes apoptotic photoreceptor cell death. Ceramide is a second messenger for apoptosis. We tested whether increases in ceramide mediate photoreceptor apoptosis in LIRD and if inhibition of ceramide synthesis protects the retina. Sprague-Dawle...

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Detalhes bibliográficos
Main Authors: Chen, Hui, Tran, Julie-Thu A., Eckerd, Annette, Huynh, Tuan-Phat, Elliott, Michael H., Brush, Richard S., Mandal, Nawajes A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3646463/
https://ncbi.nlm.nih.gov/pubmed/23468130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M035048
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