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Activity of XL184 (Cabozantinib), an Oral Tyrosine Kinase Inhibitor, in Patients With Medullary Thyroid Cancer

PURPOSE: XL184 (cabozantinib) is a potent inhibitor of MET, vascular endothelial growth factor receptor 2 (VEGFR2), and RET, with robust antiangiogenic, antitumor, and anti-invasive effects in preclinical models. Early observations of clinical benefit in a phase I study of cabozantinib, which includ...

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主要な著者: Kurzrock, Razelle, Sherman, Steven I., Ball, Douglas W., Forastiere, Arlene A., Cohen, Roger B., Mehra, Ranee, Pfister, David G., Cohen, Ezra E.W., Janisch, Linda, Nauling, Forlisa, Hong, David S., Ng, Chaan S., Ye, Lei, Gagel, Robert F., Frye, John, Müller, Thomas, Ratain, Mark J., Salgia, Ravi
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Clinical Oncology 2011
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3646303/
https://ncbi.nlm.nih.gov/pubmed/21606412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2010.32.4145
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